Democratic Senator X threatens to place a blanket hold on everything–and I mean everything–filibuster anything that does happen to make it to the floor, and generally abuse the hell out of every single parliamentary stalling tactic he can get his hands on until enough of his colleagues get fed up and agree to negotiate reform.
That sounds like it would backfire. But after hearing stories like this one, drastic measures to reform the rules of the Senate sound better and better. Unfortunately, even a retiring Senator like Evan Bayh probably doesn't want to tarnish his reputation with this sort of stunt. Fun idea, though!